冬夏季节变化对雄性金黄地鼠下丘脑垂体性腺轴功能影响的研究(1)
摘要本研究基于中医“四时五藏阴阳”理论，从代表季节变化的光照因素切入，系统性地观察了冬夏季节变化对下丘脑垂体性腺轴生理功能的影响及褪黑素在此过程中的调节作用，以探讨该理论所具有的科学内涵。实验检测了雄性金黄地鼠血浆、下丘脑、垂体、睾丸组织中MT、GnRH、LH、FSH、T的含量，以及各组织中MR的含量，结果发现，下丘脑GnRH、垂体LH、FSH、睾丸T的含量均表现为夏高冬低(P<001)，血浆中GnRH、T的含量表现为夏低冬高(P<001)，血浆FSH夏至较高，但差异无统计学意义(P>005)，血浆LH则在冬至更高(P<005)；血浆、下丘脑、睾丸中MT的含量均为夏低冬高(P<001)，垂体MT、MR含量夏至高于冬至(P<001)，下丘脑、睾丸中MR的含量则在冬至更高(P<001或P<005)。结论：下丘脑垂体性腺轴的功能呈现冬夏季节变化的特点，MT可能参与这种变化的调控，能季节性影响性腺轴激素的分泌，而生殖功能的应时調控提示机体与自然时节之间确实存在协调共振的适应性变化规律。
关键词四时五藏阴阳；褪黑素；神经内分泌；下丘脑垂体性腺轴；冬夏季节
, 百拇医药
Study on Effects of Seasonal Changes of Winter and Summer on the Function of Male
Golden Hamster′s Hypothalamicpituitarygonad Axis
Yang Zongchun1， Han Junge2， Zhang Na1， Liu Xu1， Liu Xiaoyan1，Guo Xiazhen1
(1 Beijing University of Chinese Medicine， Beijing 100029， China； 2 Beijing Fangshan
Traditional Chinese Medicine Hospital， Beijing 102488， China)
, 百拇医药
AbstractBased on the “yinyang of the four seasons and the five viscera” theory of TCM， this study systematically observed the effects of seasonal change of winter and summer on the hypothalamuspituitary gonad axis function and the role of melatonin in this seasonal change， from the representative factors into the seasonal variation of illumination， to explore the scientific connotation of this theory. The content of MT， GnRH， LH， FSH， T in the plasma， hypothalamus， pituitary and testicular tissues of male golden hamster rats were detected， and the content of MR in various tissues were detected. The results showed that the content of GnRH in hypothalamus， LH and FSH in pituitary， T in testicular were characterized by high in summer and low in winter (P<001). Content of GnRH and T in plasma was high in summer and low in winter (P<001). FSH in plasma was higher in summer， but there was no statistically significant difference (P>005). Content of LH in plasma was higher in winter (P<005)； Content of MT in plasma， the hypothalamus and testis were low in summer and high in winter (P<001)； the content of MT and MR in the pituitary gland was higher in summer than winter (P<001). The content of MR in the hypothalamus and the testes was higher in winter (P<001 or P<005). Conclusion：The function of hypothalamicpituitarygonadal axis is characterized by seasonal changes in winter and summer， and MT may be involved in the regulation of this change， which can affect the secretion of gonadotropin. The timely regulation of reproductive function suggests that there is indeed an adaptive variation law in coordination resonance between the body and the natural season., http://www.100md.com(杨宗纯 韩俊阁 张娜 刘絮 刘晓燕 郭霞珍)
关键词四时五藏阴阳；褪黑素；神经内分泌；下丘脑垂体性腺轴；冬夏季节
, 百拇医药
Study on Effects of Seasonal Changes of Winter and Summer on the Function of Male
Golden Hamster′s Hypothalamicpituitarygonad Axis
Yang Zongchun1， Han Junge2， Zhang Na1， Liu Xu1， Liu Xiaoyan1，Guo Xiazhen1
(1 Beijing University of Chinese Medicine， Beijing 100029， China； 2 Beijing Fangshan
Traditional Chinese Medicine Hospital， Beijing 102488， China)
, 百拇医药
AbstractBased on the “yinyang of the four seasons and the five viscera” theory of TCM， this study systematically observed the effects of seasonal change of winter and summer on the hypothalamuspituitary gonad axis function and the role of melatonin in this seasonal change， from the representative factors into the seasonal variation of illumination， to explore the scientific connotation of this theory. The content of MT， GnRH， LH， FSH， T in the plasma， hypothalamus， pituitary and testicular tissues of male golden hamster rats were detected， and the content of MR in various tissues were detected. The results showed that the content of GnRH in hypothalamus， LH and FSH in pituitary， T in testicular were characterized by high in summer and low in winter (P<001). Content of GnRH and T in plasma was high in summer and low in winter (P<001). FSH in plasma was higher in summer， but there was no statistically significant difference (P>005). Content of LH in plasma was higher in winter (P<005)； Content of MT in plasma， the hypothalamus and testis were low in summer and high in winter (P<001)； the content of MT and MR in the pituitary gland was higher in summer than winter (P<001). The content of MR in the hypothalamus and the testes was higher in winter (P<001 or P<005). Conclusion：The function of hypothalamicpituitarygonadal axis is characterized by seasonal changes in winter and summer， and MT may be involved in the regulation of this change， which can affect the secretion of gonadotropin. The timely regulation of reproductive function suggests that there is indeed an adaptive variation law in coordination resonance between the body and the natural season., http://www.100md.com(杨宗纯 韩俊阁 张娜 刘絮 刘晓燕 郭霞珍)
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