不同剂量米非司酮治疗更年期功血疗效的研究(1)
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【摘要】 目的 探讨不同剂量米非司酮治疗更年期功血的临床疗效，并观察其对内分泌功能的影响。方法 对确诊更年期功血患者267例随机分为3组，分别服用不同剂量米非司酮以及服用甲羟孕酮，比较应用不同剂量米非司酮治疗更年期功血的疗效、副反应情况。结果 观察1组和观察2组治愈率明显高于对照组；复发率显著低于对照组；副反应发生率观察1组明显低于观察2组。结论 服超低剂量米非司酮能诱导更年期功血患者闭经，月经规则或经量减少，副反应小，疗效安全、有效。
【关键词】
更年期功血;米非司酮;不同剂量
The effect study of different doses of mifepristone in treatment of climacteric dysfunctional uterine bleeding
MA Junhui.Department of Gynaecology and bostetrics,The People’s Hospital of Leling City,Leling 253600,China
【Abstract】 Objective
To explore different doses of mifepristone in treatment of climacteric dysfunctional uterine bleeding with clinical efficacy, and on the endocrine function of rats. Methods On the diagnosis of patients with climacteric dysfunctional uterine bleeding in 267 cases were randomly divided into three groups, respectively, taking different doses of mifepristone and medroxyprogesterone acetate, comparison and application of different doses of mifepristone in treatment of climacteric dysfunctional uterine bleeding with curative effect, adverse reaction. Results Observed in the 1 group and observation group 2 cure rate was significantly higher than that in control group,the relapse rate was significantly lower than the control group,the side reaction incidence rates were observed in the 1 groups were significantly lower than those observed in the 2 groups. Conclusion Low dose mifepristone can induce uniform climacteric dysfunctional uterine bleeding of patients with amenorrhea, menstrual regulation or by the amount of reduction, deputy reaction is little, the efficacy of safety, effective.
【Key words】
Climacteric dyslunctional uterine bleeding；
Mifepristone；Different doses
更年期功血是由于更年期妇女卵巢功能逐渐退化，剩余卵泡对于垂体促性腺激素的反应性低下，从而失去正常女性激素的周期性变化出现的不规律阴道出血。临床常见症状为子宫不规则出血，月经周期紊乱，甚至大出血。米非司酮治疗更年期功血报道屡见不鲜，但临床用药剂量及疗程存在较大争异。本文拟讨论小剂量米非司酮治疗更年期功血的疗效及其副作用报告如下。
1 临床资料
1.1 入选病例 2008年7月至2011年11月对我院均经妇科B超检查、诊断性刮宫子宫内膜病理检查、女性内分泌激素检查以及宫腔镜检查确诊。更年期功血患者267例随机分为3组，观察1组90例，观察2组90例，对照组87例。3组年龄、身高、体重、孕产次均无统计学差异。患者知情并同意。
1.2 排除病例 所有病例均行诊断性刮宫，排除内膜恶性病变。①在接受本治疗前1年内接受过其他激素治疗。②服用米非司酮禁忌证。③子宫肌瘤、子宫内膜异位症、子宫内膜癌等器质性疾病。④ 治疗前查肝肾功能异常，血常规除红细胞计数及血红蛋白值低于正常外，白细胞、血小板计数不正常。
1.3 方法 观察1、2组均分别给予米非司酮(浙江仙居制药股份有限公司生产)6 ......
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