孕妇剖宫产前后凝血四项与产后出血的相关性分析(1)
【摘要】 目的 探析孕妇剖宫产前后凝血四项与产后出血的相关性。方法 85例剖宫产产妇， 按照产后出血量情况分为研究组(出血量≥500 ml， 45例)与参照组(出血量<500 ml， 40例)。对两组产妇剖宫产前后的凝血四项指标进行检测， 并展开组间对比。结果 产前研究组纤维蛋白原(FIB)低于参照组， 凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶原时间-国际标准化比值(PT-INR)均高于参照组， 差异均具有统计学意义(P<0.05)。产后研究组FIB低于对照组， TT、APTT、PT、PT-INR均高于参照组， 差异均具有统计学意义(P<0.05)。研究组产前FIB、TT、APTT、PT与产后比较差异均无统计学意义(P>0.05) ；产前PT-INR(1.72±0.50)与产后(1.32±0.13)比较差异具有统计学意义(P<0.05)。结论 造成剖宫产产妇产后出血的一大因素即为凝血功能障碍， 因此应重视对临产孕妇产前与分娩期间的凝血指标实施监测， 以降低产后出血的发生率。
【关键词】 剖宫产；凝血；产后出血
DOI：10.14163/j.cnki.11-5547/r.2017.27.012
【Abstract】 Objective To investigate and analyze the correlation between four items of blood coagulation and postpartum hemorrhage before and after cesarean section in pregnant women. Methods A total of 85 pregnant women with cesarean section were divided by postpartum hemorrhage volume into research group (hemorrhage volume≥500 ml， 45 cases) and control group (hemorrhage volume<500 ml， 40 cases). Four items of blood coagulation before and after cesarean section in two groups was detected for comparison. Results Before delivery， the research group had lower fibrinogen (FIB) than the control group， and higher thrombin time (TT)， activated partial thromboplastin time (APTT)， prothrombin time (PT)， prothrombin time-international normalized ratio (PT-INR) than the control group. Their difference was statistically significant (P<0.05). After delivery， the research group had lower FIB than the control group， and higher TT， APTT， PT and PT-INR than the control group. Their difference was statistically significant (P<0.05). The research group had no statistically significant difference in FIB， TT， APTT， PT before delivery than after delivery (P>0.05). There was statistically significant difference in PT-INR before delivery as (1.72±0.50)， comparing with (1.32±0.13) after delivery (P<0.05). Conclusion Coagulation dysfunction is a major factor causing postpartum hemorrhage in cesarean section. Therefore， attention should be paid to the monitoring of coagulation indexes during the period of prenatal and postnatal labor in pregnant women， so as to reduce the incidence of postpartum hemorrhage.
【Key words】 Cesarean section； Blood coagulation； Postpartum hemorrhage
对产妇进行凝血四项(FIB、TT、APTT、PT/PT-INR)检测不仅有助于医护人员掌握其凝血功能情況[1]， 还能降低产后出血以及产妇死亡率。故本文就孕妇剖宫产前后凝血四项与产后出血的相关性展开研究， 现将相关成果作如下报告。
1 资料与方法
1. 1 一般资料 选取本院2015年4月～2016年11月收治的85例剖宫产产妇， 按照产后出血量情况分为研究组(出血量≥500 ml， 45例)与参照组(出血量<500 ml， 40例)。研究组平均年龄(31.54±4.08)岁；20例初产妇， 25例经产妇。参照组平均年龄(31.60±4.11)岁；18例初产妇， 22例经产妇。本次研究通过了本院伦理委员会的准许， 且参与此次研究的所有病例均签署了知情同意书。两组产妇一般资料比较差异无统计学意义(P>0.05)， 具有可比性。, 百拇医药(庄凤云 唐宁)
【关键词】 剖宫产；凝血；产后出血
DOI：10.14163/j.cnki.11-5547/r.2017.27.012
【Abstract】 Objective To investigate and analyze the correlation between four items of blood coagulation and postpartum hemorrhage before and after cesarean section in pregnant women. Methods A total of 85 pregnant women with cesarean section were divided by postpartum hemorrhage volume into research group (hemorrhage volume≥500 ml， 45 cases) and control group (hemorrhage volume<500 ml， 40 cases). Four items of blood coagulation before and after cesarean section in two groups was detected for comparison. Results Before delivery， the research group had lower fibrinogen (FIB) than the control group， and higher thrombin time (TT)， activated partial thromboplastin time (APTT)， prothrombin time (PT)， prothrombin time-international normalized ratio (PT-INR) than the control group. Their difference was statistically significant (P<0.05). After delivery， the research group had lower FIB than the control group， and higher TT， APTT， PT and PT-INR than the control group. Their difference was statistically significant (P<0.05). The research group had no statistically significant difference in FIB， TT， APTT， PT before delivery than after delivery (P>0.05). There was statistically significant difference in PT-INR before delivery as (1.72±0.50)， comparing with (1.32±0.13) after delivery (P<0.05). Conclusion Coagulation dysfunction is a major factor causing postpartum hemorrhage in cesarean section. Therefore， attention should be paid to the monitoring of coagulation indexes during the period of prenatal and postnatal labor in pregnant women， so as to reduce the incidence of postpartum hemorrhage.
【Key words】 Cesarean section； Blood coagulation； Postpartum hemorrhage
对产妇进行凝血四项(FIB、TT、APTT、PT/PT-INR)检测不仅有助于医护人员掌握其凝血功能情況[1]， 还能降低产后出血以及产妇死亡率。故本文就孕妇剖宫产前后凝血四项与产后出血的相关性展开研究， 现将相关成果作如下报告。
1 资料与方法
1. 1 一般资料 选取本院2015年4月～2016年11月收治的85例剖宫产产妇， 按照产后出血量情况分为研究组(出血量≥500 ml， 45例)与参照组(出血量<500 ml， 40例)。研究组平均年龄(31.54±4.08)岁；20例初产妇， 25例经产妇。参照组平均年龄(31.60±4.11)岁；18例初产妇， 22例经产妇。本次研究通过了本院伦理委员会的准许， 且参与此次研究的所有病例均签署了知情同意书。两组产妇一般资料比较差异无统计学意义(P>0.05)， 具有可比性。, 百拇医药(庄凤云 唐宁)