乙酰半胱氨酸泡腾片对肥胖哮喘患者气道炎症及肺功能的影响(2)
综上所述, 乙酰半胱氨酸可以抑制氧化应激反应, 减轻患者气道炎症, 改善患者肺功能, 对肥胖哮喘患者有一定的治疗价值。目前有较多关于肥胖哮喘小鼠发病机制的研究, 但临床研究仍有限, 希望能有进一步探索肥胖哮喘治疗的方法及途径。
参考文献
[1] Beuther DA. Recent insight into obesity and asthma. Curr Opin Pulm Med, 2010, 16(1):64-70.
[2] Holguin F, Fitzpatrick A. Obesity, asthma, and oxidative stress. Journal of Applied Physiology, 2010, 108(3):754-759.
[3] Calixto MC, Lintomen L, Schenka A, et al. Obesity enhances eosinophilic inflammation in a murine model of allergic asthma. Br J Pharmacol, 2010, 159(3):617-625.
[4] Schütze N, Lehmann I, Bonisch U, et al. Exposure to mycotoxins increases the allergic immune response in a murine asthma model. Am J Respir Crit Care Med, 2010, 181(11):1188-1199.
[5] 周洋, 張家洪, 黄河, 等. 乙酰半胱氨酸泡腾片对慢性阻塞性肺疾病患者炎性反应及氧化/抗氧化失衡的影响研究. 检验医学与临床, 2014, 11(5):668-669.
[6] 余江清. 乙酰半胱氨酸泡腾片合用噻托溴铵吸入剂对50例COPD合并肺气肿的临床疗效研究. 上海医药, 2016, 37(7):29-31.
[7] Gibeon D, Batuwita K, Osmond M, et al. Obesity-associated severe asthma represents a distinct clinical phenotype:analysis of the British Thoracic society Difficult Asthma Registry Patient cohort according to BMI. Chest, 2013, 143(2):406-414.
[收稿日期:2018-09-21], 百拇医药(何彩霞 张清)
参考文献
[1] Beuther DA. Recent insight into obesity and asthma. Curr Opin Pulm Med, 2010, 16(1):64-70.
[2] Holguin F, Fitzpatrick A. Obesity, asthma, and oxidative stress. Journal of Applied Physiology, 2010, 108(3):754-759.
[3] Calixto MC, Lintomen L, Schenka A, et al. Obesity enhances eosinophilic inflammation in a murine model of allergic asthma. Br J Pharmacol, 2010, 159(3):617-625.
[4] Schütze N, Lehmann I, Bonisch U, et al. Exposure to mycotoxins increases the allergic immune response in a murine asthma model. Am J Respir Crit Care Med, 2010, 181(11):1188-1199.
[5] 周洋, 張家洪, 黄河, 等. 乙酰半胱氨酸泡腾片对慢性阻塞性肺疾病患者炎性反应及氧化/抗氧化失衡的影响研究. 检验医学与临床, 2014, 11(5):668-669.
[6] 余江清. 乙酰半胱氨酸泡腾片合用噻托溴铵吸入剂对50例COPD合并肺气肿的临床疗效研究. 上海医药, 2016, 37(7):29-31.
[7] Gibeon D, Batuwita K, Osmond M, et al. Obesity-associated severe asthma represents a distinct clinical phenotype:analysis of the British Thoracic society Difficult Asthma Registry Patient cohort according to BMI. Chest, 2013, 143(2):406-414.
[收稿日期:2018-09-21], 百拇医药(何彩霞 张清)